Oral Bisphosphonate Related Osteonecrosis of the Jaws: A case report.

, Jeong, Jeom Sun; , Lee, Ju Kang

Case Report

Journal of the Korean Academy of Rehabilitation Medicine 2010;34(5):599-602.

Jeong, Jeom Sun , Lee, Ju Kang

Department of Rehabilitation, Gachon University of Medicine and Science, Korea. pm@gilhospital.com

경구 비스포스포네이트 장기 투여 이후 발생한 턱뼈 골괴사 환자 1예 − 증례 보고 −

정 점 순, 이 주 강

가천의과학대학교 재활의학교실

Abstract

Bisphosphonates are the most widely prescribed medications for the treatment of osteoporosis. However, bisphosphonate- related osteonecrosis of the jaw (BRONJ) is recently recognized as a serious complication among patients receiving bisphosphonate therapy. Most reports relate to BRONJ result from intravenous bisphosphonate or dental procedure. We report a case of mandible osteonecrosis related with oral bisphosphonate medication. A-63-year old woman suffered from toothache, cheek swelling and heating sense visited our dental clinic. She had taken oral alendronate and antihypertensive agents for 4 years because of osteoporosis and hypertension. Dental physical examination, radiologic study and pathologic study showed the severe inflammation and osteonecrosis of the mandible. Therefore we diagnosed the patient as having BRONJ and she stopped to take bisphosphonate and received surgical treatment with bone curettage. After surgical treatment and stopping bisphosphonate, her symptoms were improved. (J Korean Acad Rehab Med 2010; 34: 599-602)

Key Words: Osteoporosis, Bisphosphonate, Osteonecrosis